The Heterogeneity of the ‘y-Chain of Fetal Hemoglobin in HbS Heterozygotes
نویسنده
چکیده
patients. in 1 5 additional HbS heterozygotes. as well as in additional 55 patients, and in 35 55 and 24 AS newborn babies. The low amount of HbF in all AS adults (<1 %) made it necessary to further improve the isolation procedure of HbF, which was accomplished by introducing an HPL chromatographic method. The additional data for older 55 patients confirmed the existence of two groups characterized by either low or high G (60%) values in their HbF. A distinction into “high G.y. and “low producers could also be made for HbS heterozygotes. Family studies, however, make it unlikely that the “high condition is
منابع مشابه
On the chemical abnormality of Hb "Alexandra", a fetal hemoglobin variant.
H UMAN FETAL HEMOGLOBIN consists of two unlike pairs of polypeptide chains, i.e., a2y2. While the detection of an a-chain variant may not present serious difficulties, since the abnormal fetal hemoglobin will be replaced by the adult type, the y-chain variants are transitory and their study is limited by time, shortage of blood and their rarity. Identification of the y-chain anomaly has been po...
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